[The volatile fatty acids in children with dysfunction of biliary tract].

The volatile fatty acids are metabolites of bacteria reflecting condition and disbiotic alterations of microflora of gastrointestinal tract. The study was carried out to determine qualitatively volatile fatty acids in saliva of children with dysfunction of biliary tract and healthy ones. The indices of volatile fatty acids were analyzed in 46 children aged 7-17 years and with dysfunction of biliary tract. The comparison group included 34 healthy children aged from 7 to 17 years. The gas-liquid chromatography was applied to qualitatively detect acetic, butyric, isovaleric acids (volatile fatty acids). The automatedgas chromatograph "Crystal deluxe 4000" with capillary column "HP-FFAP" and flame ionizing detector was used. The study established decreasing of anaerobic index, increasing of acetic, propionic acids and sum of volatile fatty acids in saliva of children of main group as opposed to children of comparison group. The possible role of bacterial metabolites and bacteria in pathogenesis of dysfunction of biliary tract in children. The description is made of one of possible mechanisms of increasing of volatile fatty acids in saliva under dysfunction of biliary tract. The integral indices of volatile fatty acids of saliva are the new additional criteria for diagnostic of dysfunction of biliary tract in children.

[VOLATILE FATTY ACIDS IN SALIVA--BIOLOGICAL MARKERS FOR ASSESSMENT OF DRINKING WATER POLLUTANTS ON CHILDREN].

The use of modern methods of analysis is aimed to the search of ultimately novel biological markers. Volatile fatty acids in saliva were not used previously for the assessment of the effects of contaminating substances in the drinking water on the body of children. The aim of the study is to investigate the informative value of volatile fatty acids in saliva as biological markers of the impact for the assessment of the exposure to contaminating substances in the drinking water on the body of children. Hygienic assessment of drinking water quality was made according to data of the own research of drinking water from centralized supply system of the city of Ivanovo. For the comparison of indices there was investigated the drinking water from wells at the village Podvyaznovsky of the Ivanovo region. In the Ivanovo water from the distributing network of centralized drinking water supply system of the city of Ivanovo, there were identified indices of the permanganate oxidation and the total concentration of residual chlorine exceeding norms, and also chloroform and carbon tetrachloride were in concentrations not exceeding the norms. Studied by us the samples of drinking water from Podvyaznovsky village wells, the water met the standards for all investigated parameters. The was studied the informative value of volatile fatty acids in the saliva of children aged 9-14 years from the city of Ivanovo and the Podvyaznovsky village, Ivanovo region. There was established the fall in acetic, butyric, isovaleric acids and the total amount of volatile fatty acids in the saliva in children of the city of Ivanovo, consuming water treated with chlorine of Ivanovo centralized drinking water supply system. Indices of volatile fatty acids in saliva are informative for the assessment of the impact of organic pollutants, residual chlorine and organic chlorine compounds of drinking water on the body of children.